Details

Project TitleFast Dose Optimization for Rotating Shield Brachytherapy
Track Code2017-083
Short Description

Researchers at the University of Iowa have developed a fast computational method for calculating the optimal treatment plan for brachytherapy. This treatment planning software calculates the optimum dose to deliver to the target tumor to effectively kill the tumor and minimize off-target effects. This fast computational method allows for instantaneous optimal brachytherapy treatment planning, supporting the clinical usage of this therapy. This software would be applied to conventional high-dose-rate brachytherapy, specifically for cervical, endometrial, and breast cancer. For each of these sites, the applicators used to treat the patients make use of multiple channels, or tubes, each of which supports the delivery of an Ir-192 source on a wire. The algorithm is fast enough to reduce what would be a 2-3 minute treatment planning process to a matter of seconds - a reduction in overall time by about a factor of 20.

Abstract

High-dose-rate brachytherapy (HDR-BT) is an advanced cancer treatment commonly used to treat prostate, cervical, breast, and rectal cancers. This treatment involves the placement of radioactive pellets within and around a tumor. Unfortunately, these pellets emit radiation that not only targets the tumor, but also affects the surrounding non-cancerous tissue. Brachytherapy therefore, requires the proper positioning of radioactive pellets within a tumor to ensure significant patient benefit. However, determining the dose, placement and distribution of the pellets in a patient is a time intensive effort requiring specialized software. Specialized software applications provide detailed treatment calculations that determine the correct dose, duration of treatment and tissue response for each patient. The ability to quickly generate treatment plans that optimize the dose distribution would save time, ensure better patient experience and reduce treatment cost.

Researchers at the University of Iowa have developed a fast computational method for calculating the optimal treatment plan for brachytherapy. This treatment planning software calculates the optimum dose to deliver to the target tumor to effectively kill the tumor and minimize off-target effects. This fast computational method allows for instantaneous optimal brachytherapy treatment planning, supporting the clinical usage of this therapy. This software would be applied to conventional high-dose-rate brachytherapy, specifically for cervical, endometrial, and breast cancer. For each of these sites, the applicators used to treat the patients make use of multiple channels, or tubes, each of which supports the delivery of an Ir-192 source on a wire. The algorithm is fast enough to reduce what would be a 2-3 minute treatment planning process to a matter of seconds - a reduction in overall time by about a factor of 20.

 
Tagsradiation therapy, brachytherapy treatment plan, rotating-shield brachytherapy
 
Posted DateAug 2, 2017 3:23 PM

Licensing Contact

Kenneth Karanja, PhD

Licensing Associate,

University of Iowa Research Foundation,

2660 University Capital Center,

Iowa City, IA 52242.

Email: kenneth-karanja@uiowa.edu

Tel: 319-335-4607

University of Iowa Research Foundation

Files

File Name Description
Technical Write Up 2017-083 None Download