Details

Project TitleNovel Stilbene Antagonists of the Delta Opioid Receptor
Track Code2016-030
Short Description

Dr. Wiemer's lab has developed a novel class of stilbene antagonists with high selectivity to the delta opioid receptor. The delta receptor is not as well studied as the other opioid receptors, but it seems to play an interesting role in the development of addictive responses to treatment with prescription opioids. Therefore, this unique class of antagonist compounds can be used as a non-addictive pain medication and an effective treatment for opioid overdose. In addition, these compounds are synthesized from natural products and may be used to treat psychiatric conditions.

Abstract

Opioids function by acting on receptors (i.e. kappa, mu, and delta) located on neuronal cell membranes, inhibiting neurotransmitter release in order to produce a pleasurable effect and reduce pain. A serious side effect of prescription opioid use is opioid addiction. Approximately 9% of the population is suspected of misusing opioids and opiates. Each year, more than 15,000 people die from overdoses involving prescription opioids. Opioid antagonists are drugs that bind to opioid receptors without activating them, effectively blocking the body from responding to opioids. Some opioid antagonists have a weak opioid partial agonist effect and can act as painkillers in high doses. Others have an inverse agonist effect and can be used to treat opioid overdose.

Dr. Wiemer's lab has developed a novel class of stilbene antagonists with high selectivity to the delta opioid receptor. The delta receptor is not as well studied as the other opioid receptors, but it seems to play an interesting role in the development of addictive responses to treatment with prescription opioids. Therefore, this unique class of antagonist compounds can be used as a non-addictive pain medication and an effective treatment for opioid overdose. In addition, these compounds are synthesized from natural products and may be used to treat psychiatric conditions.

 
TagsWiemer, delta opioid receptor, non-addictive pain medication, Opioid, opioid overdose treatment, stilbene antagonist
 
Posted DateJul 24, 2017 3:33 PM

Licensing Contact

Mihaela D. Bojin, PhD, CLP

Licensing Associate

University of Iowa Research Foundation

2660 UCC

Iowa City, Iowa 52242

Phone: (319) 335-2723

Email: Mihaela-Bojin@uiowa.edu

University of Iowa Research Foundation

Files

File Name Description
Technical Write Up 2016-030 None Download