Project TitleNuclear Localized Therapeutics for Heart Disease and Skeletal Muscle Pathologies
Track Code2016-081
Short Description

Prof. Song and his lab have discovered a protein that, when truncated, is able to penetrate the nucleus of cells and transcribe the genetic coding, allowing for consistent calcium emission, which stabilizes the calcium dependent enzyme calpain. This truncated protein is able to act as a cardiac protector against hypertrophy and heart failure by way of preventing, inhibiting, or treating the issue. Since the protein also exists in skeletal muscle, the altered protein is also applicable to prevent, inhibit, or treat skeletal muscle diseases, such as muscle fatigue, muscular dystrophy, and the like.


• Reverses effects of heart failure by altering the genetic code in the JP2 protein

• Reverses effects of skeletal diseases by the same method

• Can be locally or systematically administered to prevent, inhibit, or treat issues


Patent Information: PCT Application PCT/US2017/036392

Background Information

Heart disease is the leading cause of death in the US, occurring in 1 of 16 adults. This field has a very high commercial value due to this, costing the US economy $444 billion yearly. Cardiac hypertrophy and heart failure are dangerous and all too common myocardium diseases. Mortality rates from heart disease has increased by 41% from 1990 to 2013, and has been continuing on that same trajectory. Common treatments for heart disease currently aim to lower the work load of the hearts rather than disease development. Skeletal muscle diseases and abnormalities, such as muscle fatigue and muscular dystrophy, are the leading cause of physical disability in the US. Musculoskeletal conditions such as arthritis and back pain affect 1.7 billion people worldwide and has the 4th greatest impact on the overall health of the world population when considering both death and disability.

Posted DateJul 12, 2017 4:51 PM

Licensing Contact

Mihaela Bojin

Licensing Associate | University of Iowa Research Foundation

112 N. Capitol Street | Iowa City, IA 52242-5500 | 319-335-2723

University of Iowa Research Foundation


File Name Description
Company List 16-081 muscle.csv None Download
Company List 16-081 heart.csv None Download